Lack of association between the chemokine receptor 5 polymorphism CCR5∆32 in rheumatoid arthritis and juvenile idiopathic arthritis
نویسندگان
چکیده
منابع مشابه
Considerations About the Role of the CCR5 Gene in Juvenile Idiopathic Arthritis - Look at the Whole or Put All Parts Together?
The CCR5 is an important chemockine receptor. The gene coding for this protein initially gain attention when a variant called CCR5 32 (due to the occurrence of a 32 base pair deletion in its coding region) was associated to resistance against HIV infection. Thus, homozigous CCR5 32 individuals were shown to be protected against HIV-1 infection and heterozigous individuals presented a delay on A...
متن کاملStudy of CCR5 Gene Polymorphism in Rheumatoid Arthritis
Chemokines are critical for the inflammatory process in autoimmune diseases such as rheumatoid arthritis (RA). The chemokine receptor-5 (CCR5) mediates chemotaxis by CC chemokines and is expressed by lymphocytes with Th1 phenotype and monocyte/macrophages. A 32bp deletion in the CCR5 (CCR5-delta 32 allele) abolishes receptor expression in homozygotes, while CCR5-delta 32 carriers express less r...
متن کاملAssociation of the CCR5Δ32 variant with juvenile idiopathic arthritis in a meta-analysis
Background CCR5 is expressed on Th1 cells and may play a role in Rheumatoid Arthritis by recruiting these cells to the synovium, where they drive an inflammatory process. The CCR5Δ32 variant, a deletion variant which leads to a dysfunctional receptor, has been reported in several genetic association studies in Juvenile Idiopathic Arthritis (JIA), with conflicting results. CCL14 is one of the li...
متن کاملLack of Association between PTPN22 (+1858 C>T) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran
Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA ...
متن کاملCONCISE REPORT Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis
Background: Ligands of chemokine receptor CCR5, including MIP-1a, MIP-1b, and RANTES, have been implicated in rheumatoid arthritis. Objective: To test whether CCR5 d32 polymorphism has a negative association with rheumatoid arthritis in a New Zealand cohort. Methods: 516 white patients with rheumatoid arthritis and 985 healthy controls were investigated by PCR amplification of the region flanki...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2006